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Rome is an enchanting Italian city that attracts visitors from across the globe. There is much to see and explore in the eternal city. And if your itinerary involves venturing beyond the city limits, then driving from Rome to Venice could be an exciting road trip adventure filled with countless attractions. With some great stops along the way, including Florence, Bologna, Siena, Padua, Perugia, Ferrara, Orvieto, Modena, San Gimignano, and Arezzo, you can plan a multi day trip and experience the stretch of journey in the comfort and convenience of a self drive car rental.
Travelling between the iconic cities of Rome and Venice combines the best of Italy’s urban charm with countryside allure. From soaking in the views of the charming Tuscan landscape, glittering Mediterranean coast, picturesque hill towns, vibrant urban dining spots, and awe-inspiring natural reserves, this scenic route has something for everyone. The best times to experience the ultimate road trip from Rome to Venice are spring and fall, when there is a lower influx of tourists. Therefore, it makes sense to hire a car and experience the flexibility and convenience of exploring countless destinations at your own pace. Refer to our carefully compiled guide for travelling from Rome to Venice in a rental car and experience the freedom to explore some of the more off-the-beaten-path destinations on your trip.

Italy offers beautiful one-way road trips from Italy. Explore this list of the best road trips from Milan, and you can easily rent a self-drive vehicle through us for an unforgettable journey on any or all of these routes.
| Popular Car Rental Pick Up Locations in Rome | Fiumicino Airport, Ciampino Airport, Rome Termini Station, Tiburtina Railway Station, San Basilio, Rome Downtown |
| Popular Car Rental Drop Off Locations in Venice | Venice Marco Polo Airport, Santa Lucia Train Station, Mestre Railway Station, Venice Downtown, Port |
| Most Popular Car Types | SUV and Economy |
| Average Daily Price for Rome to Venice One Way Rental | EUR 19.12 / per day |
| Best Car Rental Companies | Sixt, Europcar, Noleggiare, Locauto, Maggiore |
| Route | Estimated Distance | Drive Time (excluding stops) | Key City Stops | Route Highlights |
|---|---|---|---|---|
| Via E35 | 530 km (329 miles) | 5 hr 48 min | Oriveto, Bologna, Florence, Moderna, Verona, Padua, | Colosseum, Duomo di Orvieto, Pozzo di San Patrizio, Ponte Vecchio, Uffizi Gallery, Leonardo da Vinci Museum, Piazza Maggiore, Museo Ferrari, Arena di Verona, Scrovegni Chapel, Piazza San Marco |
| Via Strada Statale 3 bis (Centrale Umbra) | 556 km (345 miles) | 6 hr 19 min | Otricoli, Narni, Terni, Spoleto, Foligno, Assisi, Perugia, Gubbio, Urbina, Pesaro, Rimini, Bologna, Ferrara, Padua | Vatican Museum, Otricoli Archaeological Park, Narni Sotterranea, Centro Storico, Ponte delle Torri, Piazza della Repubblica, Basilica of Saint Francis, National Gallery of Umbria, Palazzo dei Consoli, Palazzo Ducale, Villa Imperiale, Arch of Augustus, Asinelli Tower, Castello Estense, Prato della Valle, Rialto Bridge |
| Via SS3bis and SS309 (Romea) | 499 km (310 miles) | 6 hr 38 min | Otricoli, Narni, Terni, Spoleto, Foligno, Assisi, Perugia, Gubbio, Urbina, Pesaro, Ravenna, Comacchio, Chioggia, | Villa Borghese, Rocca Albornoziana, Cascata delle Marmore, Spoleto Cathedral, Church of Santa Maria Infraportas, Basilica of Santa Chiara, Piazza IV Novembre, Funivia Colle Eletto, Orto Botanico, Piazza del Popolo, Mosaics of Ravenna, Comacchio’s Historic Center, Corso del Popolo, Doge’s Palace |
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